1vrq

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Revision as of 20:59, 24 November 2007

Image:1vrq.gif

Crystal Structure of Heterotetrameric Sarcosine Oxidase from Corynebacterium sp. U-96 in complex with Folinic Acid

Overview

Sarcosine oxidase from Corynebacterium sp. U-96 is a heterotetrameric, enzyme. Here we report the crystal structures of the enzyme in complex, with dimethylglycine and folinic acid. The alpha subunit is composed of, two domains, contains NAD(+), and binds folinic acid. The beta subunit, contains dimethylglycine, FAD, and FMN, and these flavins are, approximately 10A apart. The gamma subunit is in contact with two domains, of alpha subunit and has possibly a folate-binding structure. The delta, subunit contains a single atom of zinc and has a Cys(3)His zinc finger, structure. Based on the structures determined and on the previous works, the structure-function relationship on the heterotetrameric sarcosine, oxidase is discussed.

About this Structure

1VRQ is a Protein complex structure of sequences from Corynebacterium sp. with ZN, SO4, FAD, NAD, FON, FMN and DMG as ligands. Active as Sarcosine oxidase, with EC number 1.5.3.1 Full crystallographic information is available from OCA.

Reference

Crystal structure of heterotetrameric sarcosine oxidase from Corynebacterium sp. U-96., Ida K, Moriguchi T, Suzuki H, Biochem Biophys Res Commun. 2005 Jul 29;333(2):359-66. PMID:15946648

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