1f1m
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(New page: 200px<br /><applet load="1f1m" size="450" color="white" frame="true" align="right" spinBox="true" caption="1f1m, resolution 1.80Å" /> '''CRYSTAL STRUCTURE OF...)
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Revision as of 21:00, 24 November 2007
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CRYSTAL STRUCTURE OF OUTER SURFACE PROTEIN C (OSPC)
Overview
Outer surface protein C (OspC) is a major antigen on the surface of the, Lyme disease spirochete, Borrelia burgdorferi, when it is being, transmitted to humans. Crystal structures of OspC have been determined for, strains HB19 and B31 to 1.8 and 2.5 A resolution, respectively. The, three-dimensional structure is predominantly helical. This is in contrast, to the structure of OspA, a major surface protein mainly present when, spirochetes are residing in the midgut of unfed ticks, which is mostly, beta-sheet. The surface of OspC that would project away from the, spirochete's membrane has a region of strong negative electrostatic, potential which may be involved in binding to positively charged host, ligands. This feature is present only on OspCs from strains known to cause, invasive human disease.
About this Structure
1F1M is a Single protein structure of sequence from Borrelia burgdorferi with ZN as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi., Kumaran D, Eswaramoorthy S, Luft BJ, Koide S, Dunn JJ, Lawson CL, Swaminathan S, EMBO J. 2001 Mar 1;20(5):971-8. PMID:11230121
Page seeded by OCA on Sat Nov 24 23:08:21 2007
Categories: Borrelia burgdorferi | Single protein | Dunn, J.J. | Eswaramoorthy, S. | Kumaran, D. | Swaminathan, S. | ZN | Dimer | Hb19 | Helical bundle | Lyme disease | Ospc
