3gw5

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3gw5.jpg|left|200px]]
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The entry 3gw5 is ON HOLD until Paper Publication
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{{STRUCTURE_3gw5| PDB=3gw5 | SCENE= }}
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Authors: Wu, Z., McKeever, B.M.
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===Crystal structure of human renin complexed with a novel inhibitor===
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Description: Crystal structure of human renin complexed with a novel inhibitor
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 09:40:07 2009''
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{{ABSTRACT_PUBMED_19457666}}
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==Disease==
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Known disease associated with this structure: Renal tubular dysgenesis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=179820 179820]], Hyperproreninemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=179820 179820]]
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==About this Structure==
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3GW5 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GW5 OCA].
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==Reference==
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<ref group="xtra">PMID:19457666</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Renin]]
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[[Category: McKeever, B M.]]
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[[Category: Wu, Z.]]
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[[Category: Alternative splicing]]
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[[Category: Aspartate protease]]
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[[Category: Aspartyl protease]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Crystal structure]]
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[[Category: Disease mutation]]
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[[Category: Disulfide bond]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase/hydrolase inhibitor complex]]
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[[Category: Hypertension]]
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[[Category: Membrane]]
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[[Category: Polymorphism]]
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[[Category: Protease]]
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[[Category: Renin]]
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[[Category: Renin expression]]
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[[Category: Renin inhibitor]]
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[[Category: Secreted]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 25 09:04:36 2009''

Revision as of 06:04, 25 June 2009

Image:3gw5.jpg

Template:STRUCTURE 3gw5

Contents

Crystal structure of human renin complexed with a novel inhibitor

Template:ABSTRACT PUBMED 19457666

Disease

Known disease associated with this structure: Renal tubular dysgenesis OMIM:[179820], Hyperproreninemia OMIM:[179820]

About this Structure

3GW5 is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Tice CM, Xu Z, Yuan J, Simpson RD, Cacatian ST, Flaherty PT, Zhao W, Guo J, Ishchenko A, Singh SB, Wu Z, Scott BB, Bukhtiyarov Y, Berbaum J, Mason J, Panemangalore R, Cappiello MG, Muller D, Harrison RK, McGeehan GM, Dillard LW, Baldwin JJ, Claremon DA. Design and optimization of renin inhibitors: Orally bioavailable alkyl amines. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3541-5. Epub 2009 May 5. PMID:19457666 doi:10.1016/j.bmcl.2009.04.140

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