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User:Tilman Schirmer/Sandbox 204

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(Protomer)
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'''''WspR'''''
'''''WspR'''''
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== Intro ==
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== Overview ==
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== Domain structure ==
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== Protomer ==
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<applet load='2bre' scene='User:Tilman_Schirmer/Sandbox_204/Protomer/3' size='300' frame='true' align='right' caption='3bre' />
<applet load='2bre' scene='User:Tilman_Schirmer/Sandbox_204/Protomer/3' size='300' frame='true' align='right' caption='3bre' />

Revision as of 20:32, 30 June 2009

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WspR

Contents

Overview

3bre

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: ,

from Pseudomonas aeruginosa is a response regulator with an unorthodox catalytic, diguanylate cyclase, output domain. It is composed of a canonical CheY-like response regulator receiver () domain and a C-terminal domain that confers the catalytic acitvity.




Although not modified (e.g. phosphorylated) at the active Asp (Asp70), WspR is found in the form with the contact mediated by the Rec domains.










Allosteric product binding site

3bre

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Primary inhibition site (Ip)


Secondary inhibition site (Is)

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Primary and secondary inhibition sites





Two conformations

Non-activated conformation


















Activated conformation


















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Tilman Schirmer

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