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User:Tilman Schirmer/Sandbox 204
From Proteopedia
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<scene name='User:Tilman_Schirmer/Sandbox_204/Prim_sec_inhibition_site_c2e/1'>Primary and secondary inhibition sites + C2E</scene> | <scene name='User:Tilman_Schirmer/Sandbox_204/Prim_sec_inhibition_site_c2e/1'>Primary and secondary inhibition sites + C2E</scene> | ||
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| - | == Two conformations == | ||
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| - | == Non-activated conformation == | ||
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| - | == Activated conformation == | ||
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| - | <br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br> | ||
Revision as of 20:37, 30 June 2009
WspR
Contents |
Overview
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: ,
from Pseudomonas aeruginosa is a response regulator with an unorthodox catalytic, diguanylate cyclase, output domain. It is composed of a canonical CheY-like response regulator receiver () domain and a C-terminal domain that confers the catalytic acitvity.
Although not modified (e.g. phosphorylated) at the active Asp (Asp70), WspR is found in the form with the contact mediated by the Rec domains.
Allosteric product binding site
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Primary inhibition site (Ip)
Secondary inhibition site (Is)
Is this correct?
Allosteric binding of the product c-di-GMP
C-di-GMP binding to the inhbition sites cross-links two dimers.
