1w3z

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(New page: 200px<br /><applet load="1w3z" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w3z, resolution 3.2&Aring;" /> '''SEMET DERIVATIVE OF B...)
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Revision as of 21:14, 24 November 2007

Image:1w3z.gif

1w3z, resolution 3.2Å

Drag the structure with the mouse to rotate

SEMET DERIVATIVE OF BBCRASP-1 FROM BORRELIA BURGDORFERI

Overview

Borrelia burgdorferi, a spirochete transmitted to human hosts during, feeding of infected Ixodes ticks, is the causative agent of Lyme disease., Serum-resistant B. burgdorferi strains cause a chronic, multisystemic form, of the disease and bind complement factor H (FH) and FH-like protein 1, (FHL-1) on the spirochete surface. Here we report the atomic structure for, the key FHL-1- and FH-binding protein BbCRASP-1 and reveal a homodimer, that presents a novel target for drug design.

About this Structure

1W3Z is a Single protein structure of sequence from Borrelia burgdorferi. Full crystallographic information is available from OCA.

Reference

A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi., Cordes FS, Roversi P, Kraiczy P, Simon MM, Brade V, Jahraus O, Wallis R, Skerka C, Zipfel PF, Wallich R, Lea SM, Nat Struct Mol Biol. 2005 Mar;12(3):276-7. Epub 2005 Feb 13. PMID:15711564

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