1f84
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(New page: 200px<br /><applet load="1f84" size="450" color="white" frame="true" align="right" spinBox="true" caption="1f84" /> '''SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN II...)
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Revision as of 21:20, 24 November 2007
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SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIID
Overview
Translation of the hepatitis C virus (HCV) polyprotein is initiated at an, internal ribosome entry site (IRES) element in the 5' untranslated region, of HCV RNA. The HCV IRES element interacts directly with the 40S subunit, and biochemical experiments have implicated RNA elements near the AUG, start codon as required for IRES-40S subunit complex formation. The data, we present here show that two RNA stem loops, domains IIId and IIIe, are, involved in IRES-40S subunit interaction. The structures of the two RNA, domains were solved by NMR spectroscopy and reveal structural features, that may explain their role in IRES function.
About this Structure
1F84 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structures of two RNA domains essential for hepatitis C virus internal ribosome entry site function., Lukavsky PJ, Otto GA, Lancaster AM, Sarnow P, Puglisi JD, Nat Struct Biol. 2000 Dec;7(12):1105-10. PMID:11101890
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