1jes

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Revision as of 21:25, 24 November 2007

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spinqualitylabelsall models 1jes, resolution 1.5Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystal Structure of a Copper-Mediated Base Pair in DNA

Overview

Stable and selective DNA base pairing by metal coordination was recently, demonstrated with nucleotides containing complementary, pyridine-2,6-dicarboxylate (Dipic) and pyridine (Py) bases (Meggers, E.;, Holland, P. L.; Tolman; W. B.; Romesberg, F. E.; Schultz, P. G. J. Am., Chem. Soc. 2000, 122, 10714-10715). To understand the structural, consequences of introducing this novel base pair into DNA we have solved, the crystal structure of a duplex containing the metallo-base pair. The, structure shows that the bases pair as designed, but in a Z-DNA, conformation. The structure also provides a structural explanation for the, B- to Z-DNA transition in this duplex. Further solution studies, demonstrate that the metallo-base pair is compatible with Z- or B-DNA, conformations, depending on the duplex sequence.

About this Structure

1JES is a Protein complex structure of sequences from [1] with CU as ligand. Full crystallographic information is available from OCA.

Reference

Structure of a copper-mediated base pair in DNA., Atwell S, Meggers E, Spraggon G, Schultz PG, J Am Chem Soc. 2001 Dec 12;123(49):12364-7. PMID:11734038

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