1w9n
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(New page: 200px<br /><applet load="1w9n" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w9n" /> '''ISOLATION AND CHARACTERIZATION OF EPILANCIN ...)
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Revision as of 21:29, 24 November 2007
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ISOLATION AND CHARACTERIZATION OF EPILANCIN 15X, A NOVEL ANTIBIOTIC FROM A CLINICAL STRAIN OF STAPHYLOCOCCUS EPIDERMIDIS
Overview
The potential application of lantibiotics as food-preserving agents and, more recently as antibiotics has strongly increased the interest in these, antibacterial peptides. Here, we report the elucidation of the primary and, three-dimensional structures of the novel lantibiotic epilancin 15X from, Staphylococcus epidermidis using high-resolution nuclear magnetic, resonance spectroscopy and tandem mass spectrometry. The molecule contains, ten post-translationally modified amino acids, three lanthionine ring, structures and a hydroxy-propionyl N-terminal moiety. The primary and, tertiary structure and the distribution of positive charges are closely, similar to the previously identified lantibiotic epilancin K7, most likely, indicative of a common mode of action.
About this Structure
1W9N is a Single protein structure of sequence from Staphylococcus epidermidis. Full crystallographic information is available from OCA.
Reference
Isolation and structural characterization of epilancin 15X, a novel lantibiotic from a clinical strain of Staphylococcus epidermidis., Ekkelenkamp MB, Hanssen M, Danny Hsu ST, de Jong A, Milatovic D, Verhoef J, van Nuland NA, FEBS Lett. 2005 Mar 28;579(9):1917-22. PMID:15792796
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