1gkc
From Proteopedia
(New page: 200px<br /> <applet load="1gkc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gkc, resolution 2.30Å" /> '''MMP9-INHIBITOR COMP...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GKC is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA, ZN and BUM as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.35 3.4.24.35]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GKC OCA]]. | + | 1GKC is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA, ZN and BUM as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Hydrolase Hydrolase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.35 3.4.24.35]]. Structure known Active Site: BUA. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GKC OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: matrix metalloprotease]] | [[Category: matrix metalloprotease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:28:47 2007'' |
Revision as of 06:24, 30 October 2007
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MMP9-INHIBITOR COMPLEX
Overview
Matrix metalloproteinases (MMPs) and their inhibitors are important in, connective tissue re-modelling in diseases of the cardiovascular system, such as atherosclerosis. Various members of the MMP family have been shown, to be expressed in atherosclerotic lesions, but MMP9 is consistently seen, in inflammatory atherosclerotic lesions. MMP9 over-expression is, implicated in the vascular re-modelling events preceding plaque rupture, (the most common cause of acute myocardial infarction). Reduced MMP9, activity, either by genetic manipulation or through pharmacological, intervention, has an impact on ventricular re-modelling following, infarction. MMP9 activity may therefore represent a key mechanism in the, pathogenesis of heart failure. We have determined the crystal structure, at 2.3 A ... [(full description)]
About this Structure
1GKC is a [Single protein] structure of sequence from [Homo sapiens] with CA, ZN and BUM as [ligands]. Active as [Hydrolase], with EC number [3.4.24.35]. Structure known Active Site: BUA. Full crystallographic information is available from [OCA].
Reference
Crystal structure of human MMP9 in complex with a reverse hydroxamate inhibitor., Rowsell S, Hawtin P, Minshull CA, Jepson H, Brockbank SM, Barratt DG, Slater AM, McPheat WL, Waterson D, Henney AM, Pauptit RA, J Mol Biol. 2002 May 24;319(1):173-81. PMID:12051944
Page seeded by OCA on Tue Oct 30 08:28:47 2007
Categories: Homo sapiens | Single protein | Pauptit, R.A. | Rowsell, S. | BUM | CA | ZN | Glycoprotein | Hydrolase | Matrix metalloprotease
