1ji8
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(New page: 200px<br /><applet load="1ji8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ji8" /> '''Solution Structure of Pyrobaculum Aerophilum...)
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Revision as of 21:33, 24 November 2007
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Solution Structure of Pyrobaculum Aerophilum DsrC/gamma subunit of dissimilatory sulfite reductase
Overview
The solution structure of DsrC, an archaeal homologue of the gamma subunit, of dissimilatory sulfite reductase, has been determined by NMR, spectroscopy. This 12.7-kDa protein from the hyperthermophilic archaeon, Pyrobaculum aerophilum adopts a novel fold consisting of an orthogonal, helical bundle with a beta hairpin along one side. A portion of the, structure resembles the helix-turn-helix DNA-binding motif common in, transcriptional regulator proteins. The protein contains two disulfide, bonds but remains folded following reduction of the disulfides. DsrC, proteins from organisms other than Pyrobaculum species do not contain, these disulfide bonds. A conserved cysteine next to the C-terminus, which, is not involved in the disulfide bonds, is located on a seven-residue, C-terminal arm that is not part of the globular protein and is likely to, dynamically sample more than one conformation.
About this Structure
1JI8 is a Single protein structure of sequence from Pyrobaculum aerophilum. Full crystallographic information is available from OCA.
Reference
Solution structure of Pyrobaculum aerophilum DsrC, an archaeal homologue of the gamma subunit of dissimilatory sulfite reductase., Cort JR, Mariappan SV, Kim CY, Park MS, Peat TS, Waldo GS, Terwilliger TC, Kennedy MA, Eur J Biochem. 2001 Nov;268(22):5842-50. PMID:11722571
Page seeded by OCA on Sat Nov 24 23:40:38 2007
