3hkj

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3hkj.jpg|left|200px]]
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The entry 3hkj is ON HOLD until Paper Publication
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{{STRUCTURE_3hkj| PDB=3hkj | SCENE= }}
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Authors: Gandhi, P.S., Page, M.J., Chen, Z., Bush-Pelc, L., Di Cera, E.
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===Crystal structure of human thrombin mutant W215A/E217A in complex with the extracellular fragment of human PAR1===
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Description: Crystal structure of human thrombin mutant W215A/E217A in complex with the extracellular fragment of human PAR1
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 17 09:46:18 2009''
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==Disease==
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Known disease associated with this structure: Dysprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hyperprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hypoprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]]
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==About this Structure==
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3HKJ is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKJ OCA].
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==Reference==
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<ref group="xtra">PMID:15252033</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Thrombin]]
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[[Category: Bush-Pelc, L.]]
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[[Category: Cera, E Di.]]
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[[Category: Chen, Z.]]
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[[Category: Gandhi, P S.]]
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[[Category: Page, M J.]]
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[[Category: Acute phase]]
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[[Category: Blood coagulation]]
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[[Category: Calcium]]
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[[Category: Cell membrane]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Disease mutation]]
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[[Category: Disulfide bond]]
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[[Category: G-protein coupled receptor]]
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[[Category: Gamma-carboxyglutamic acid]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Kringle]]
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[[Category: Membrane]]
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[[Category: Pharmaceutical]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Protease]]
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[[Category: Receptor]]
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[[Category: Secreted]]
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[[Category: Serine protease]]
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[[Category: Transducer]]
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[[Category: Transmembrane]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 8 12:45:00 2009''

Revision as of 09:45, 8 July 2009

Image:3hkj.jpg

Template:STRUCTURE 3hkj

Contents

Crystal structure of human thrombin mutant W215A/E217A in complex with the extracellular fragment of human PAR1

Disease

Known disease associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]

About this Structure

3HKJ is a 6 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Pineda AO, Chen ZW, Caccia S, Cantwell AM, Savvides SN, Waksman G, Mathews FS, Di Cera E. The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket. J Biol Chem. 2004 Sep 17;279(38):39824-8. Epub 2004 Jul 13. PMID:15252033 doi:http://dx.doi.org/10.1074/jbc.M407272200

Page seeded by OCA on Wed Jul 8 12:45:00 2009

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