1wd5
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(New page: 200px<br /><applet load="1wd5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wd5, resolution 2.00Å" /> '''Crystal structure of...)
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Revision as of 21:38, 24 November 2007
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Crystal structure of TT1426 from Thermus thermophilus HB8
Overview
TT1426, from Thermus thermophilus HB8, is a conserved hypothetical protein, with a predicted phosphoribosyltransferase (PRTase) domain, as revealed by, a Pfam database search. The 2.01 A crystal structure of TT1426 has been, determined by the multiwavelength anomalous dispersion (MAD) method., TT1426 comprises a core domain consisting of a central five-stranded beta, sheet surrounded by four alpha-helices, and a subdomain in the C terminus., The core domain structure resembles those of the type I PRTase family, proteins, although a significant structural difference exists in an, inserted 43-residue region. The C-terminal subdomain corresponds to the, "hood," which contains a substrate-binding site in the type I PRTases. The, hood structure of TT1426 differs from those of the other type I PRTases, suggesting the possibility that TT1426 binds an unknown substrate. The, structure-based sequence alignment provides clues about the amino acid, residues involved in catalysis and substrate binding.
About this Structure
1WD5 is a Protein complex structure of sequences from Thermus thermophilus with MES as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of a predicted phosphoribosyltransferase (TT1426) from Thermus thermophilus HB8 at 2.01 A resolution., Kukimoto-Niino M, Shibata R, Murayama K, Hamana H, Nishimoto M, Bessho Y, Terada T, Shirouzu M, Kuramitsu S, Yokoyama S, Protein Sci. 2005 Mar;14(3):823-7. Epub 2005 Feb 2. PMID:15689504
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