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1spu

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(New page: 200px<br /> <applet load="1spu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1spu, resolution 2.0&Aring;" /> '''STRUCTURE OF OXIDORE...)
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==About this Structure==
==About this Structure==
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1SPU is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with CU and CA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.6 1.4.3.6]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SPU OCA]].
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1SPU is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with CU and CA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.6 1.4.3.6]]. Structure known Active Sites: CUA, CUB, M1A, M1B, M2A and M2B. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SPU OCA]].
==Reference==
==Reference==
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[[Category: tpq]]
[[Category: tpq]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 16:09:08 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:29:46 2007''

Revision as of 06:25, 30 October 2007

Image:1spu.gif

1spu, resolution 2.0Å

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STRUCTURE OF OXIDOREDUCTASE

Overview

The crystal structure of the complex between the copper amine oxidase from, Escherichia coli (ECAO) and a covalently bound inhibitor, 2-hydrazinopyridine, has been determined to a resolution of 2.0 A. The, inhibitor covalently binds at the 5 position of the quinone ring of the, cofactor, 2,4,5-trihydroxyphenylalaninequinone (TPQ). The inhibitor, complex is analogous to the substrate Schiff base formed during the, reaction with natural monoamine substrate. A proton is abstracted from a, methylene group adjacent to the amine group by a catalytic base during the, reaction. The inhibitor, however, has a nitrogen at this position, preventing proton abstraction and trapping the enzyme in a covalent, complex. The electron density shows this nitrogen is hydrogen bonded to, the side chain of ... [(full description)]

About this Structure

1SPU is a [Single protein] structure of sequence from [Escherichia coli] with CU and CA as [ligands]. Active as [Oxidoreductase], with EC number [1.4.3.6]. Structure known Active Sites: CUA, CUB, M1A, M1B, M2A and M2B. Full crystallographic information is available from [OCA].

Reference

Catalytic mechanism of the quinoenzyme amine oxidase from Escherichia coli: exploring the reductive half-reaction., Wilmot CM, Murray JM, Alton G, Parsons MR, Convery MA, Blakeley V, Corner AS, Palcic MM, Knowles PF, McPherson MJ, Phillips SE, Biochemistry. 1997 Feb 18;36(7):1608-20. PMID:9048544

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