1nxi

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Revision as of 21:50, 24 November 2007

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Solution structure of Vibrio cholerae protein VC0424

Overview

The structure of Vibrio cholerae protein VC0424 was determined by NMR, spectroscopy. VC0424 belongs to a conserved family of bacterial proteins, of unknown function (COG 3076). The structure has an alpha-beta sandwich, architecture consisting of two layers: a four-stranded antiparallel, beta-sheet and three side-by-side alpha-helices. The secondary structure, elements have the order alphabetaalphabetabetaalphabeta along the, sequence. This fold is the same as the ferredoxin-like fold, except with, an additional long N-terminal helix, making it a variation on this common, motif. A cluster of conserved surface residues on the beta-sheet side of, the protein forms a pocket that may be important for the biological, function of this conserved family of proteins.

About this Structure

1NXI is a Single protein structure of sequence from Vibrio cholerae. Full crystallographic information is available from OCA.

Reference

Solution structure of Vibrio cholerae protein VC0424: a variation of the ferredoxin-like fold., Ramelot TA, Ni S, Goldsmith-Fischman S, Cort JR, Honig B, Kennedy MA, Protein Sci. 2003 Jul;12(7):1556-61. PMID:12824501

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