1nyd
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(New page: 200px<br /><applet load="1nyd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nyd" /> '''Solution structure of DNA quadruplex GCGGTGG...)
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Revision as of 21:55, 24 November 2007
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Solution structure of DNA quadruplex GCGGTGGAT
Overview
The structure formed by the DNA sequence d(GCGGTGGAT) in a 100 mM Na(+), solution has been determined using molecular dynamics calculations, constrained by distance and dihedral restraints derived from NMR, experiments performed at isotopic natural abundance. The sequence folds, into a dimer of dimers. Each symmetry-related half contains two parallel, stranded G:G:G:G tetrads flanked by an A:A mismatch and by four-stranded, G:C:G:C tetrads. Each of the two juxtaposed G:C:G:C tetrads is composed of, alternating antiparallel strands from the two halves of the dimer. For, each single strand, a thymine intersperses a double chain reversal, connecting the juxtaposed G:G:G:G tetrads. This architecture has potential, implications in genetic recombination. It suggests a pathway for, oligomerization involving association of quadruplex entities through GpC, steps.
About this Structure
1NYD is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Association of DNA quadruplexes through G:C:G:C tetrads. Solution structure of d(GCGGTGGAT)., Webba da Silva M, Biochemistry. 2003 Dec 16;42(49):14356-65. PMID:14661946
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