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1s9b
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(New page: 200px<br /><applet load="1s9b" size="450" color="white" frame="true" align="right" spinBox="true" caption="1s9b, resolution 2.81Å" /> '''Crystal Structure An...)
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Revision as of 21:58, 24 November 2007
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Crystal Structure Analysis of the B-DNA GAATTCG
Overview
DNA oligonucleotides can be used in order to assemble highly structured, materials. Oligonucleotides with sticky ends can form long linear, structures, whereas branching is required to form two- and, three-dimensional nanostructures. In this paper, we show that when Ni(2+), is attached to the N7 atom of guanine, it can also act as a branching, point. Thus, we have found that the heptanucleotide d(GAATTCG) can, assemble into long linear duplex structures, which cross in space to, generate a cubic structure. The three-dimensional arrays are stabilized by, phosphate-Ni(2+)-guanine interactions. For the first time, the, crystallization of a B form DNA oligonucleotide in a cubic system is, reported, space group I23. Large solvent cavities are found among the DNA, duplexes.
About this Structure
1S9B is a Protein complex structure of sequences from [1] with NI as ligand. Full crystallographic information is available from OCA.
Reference
A cubic arrangement of DNA double helices based on nickel-guanine interactions., Valls N, Uson I, Gouyette C, Subirana JA, J Am Chem Soc. 2004 Jun 30;126(25):7812-6. PMID:15212528
Page seeded by OCA on Sun Nov 25 00:06:24 2007
Categories: Protein complex | Gouyette, C. | Subirana, J.A. | Uson, I. | Valls, N. | NI | Cubic dna | Double helix | Nickel
