1h7q
From Proteopedia
(New page: 200px<br /> <applet load="1h7q" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h7q, resolution 2.00Å" /> '''DTDP-MANGANESE COMP...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1H7Q is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]] with MN, MG and TYD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H7Q OCA]]. | + | 1H7Q is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]] with MN, MG and TYD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H7Q OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:31:35 2007'' |
Revision as of 06:26, 30 October 2007
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DTDP-MANGANESE COMPLEX OF SPSA FROM BACILLUS SUBTILIS
Overview
The vast majority of glycosidic-bond synthesis in nature is performed by, glycosyltransferases, which use activated glycosides as the sugar donor., Typically, the activated leaving group is a nucleoside phosphate, lipid, phosphate or phosphate. The nucleotide-sugar-dependent, glycosyltransferases fall into over 50 sequence-based families, with the, largest and most widespread family of inverting transferases named family, GT-2. Here, we present the three-dimensional crystal structure of SpsA, the first and currently the only structural representative from family, GT-2, in complex with both Mn-dTDP and Mg-dTDP at a resolution of 2 A., These structures reveal how SpsA and related enzymes may display, nucleotide plasticity and permit a comparison of the catalytic centre of, this enzyme with ... [(full description)]
About this Structure
1H7Q is a [Single protein] structure of sequence from [Bacillus subtilis] with MN, MG and TYD as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Three-dimensional structures of the Mn and Mg dTDP complexes of the family GT-2 glycosyltransferase SpsA: a comparison with related NDP-sugar glycosyltransferases., Tarbouriech N, Charnock SJ, Davies GJ, J Mol Biol. 2001 Dec 7;314(4):655-61. PMID:11733986
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