1bn9
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(New page: 200px<br /><applet load="1bn9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bn9" /> '''RESPONSE ELEMENT OF THE ORPHAN NUCLEAR RECEP...)
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Revision as of 22:15, 24 November 2007
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RESPONSE ELEMENT OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB BETA
Overview
Rev-erb beta is an orphan receptor that binds as a homodimer or as a, monomer to DNA. The solution structure of the non-palindromic 15 bp DNA, duplex d(TAGAATGTAGGTCAG), the response element of Rev-erb beta for, monomeric binding, was determined by 1H and 31P NMR, energy minimization, with NMR-derived restraints for distances and NOE back-calculation, methods. The refined final structures have the typical overall features of, B-type DNA. However, titration of this 15 bp duplex with ReDBD, the DNA, binding domain of Rev-erb beta, showed large shifts of imino protons and, 31P signals, suggesting major conformational changes.
About this Structure
1BN9 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Solution structure of the orphan nuclear receptor rev-erb beta response element by 1H, 31P NMR and molecular simulation*., Castagne C, Terenzi H, Zakin MM, Delepierre M, Biochimie. 2000 Aug;82(8):739-48. PMID:11018291
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