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1jy5
From Proteopedia
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(New page: 200px<br /><applet load="1jy5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jy5, resolution 2.05Å" /> '''RNase-related protei...)
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Revision as of 22:17, 24 November 2007
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RNase-related protein from Calystegia sepium
Overview
The structure of a catalytically inactive RNase-related protein from, Calystegia sepium (CalsepRRP) has been resolved by protein crystallography, at a resolution of 2.05 A and an R factor of 20.74%. Although the protein, is completely devoid of ribonuclease activity, it adopts the typical alpha, + beta structure of non-base-specific RNases. Analysis of the structure, revealed that two amino-acid substitutions in the 'active' P1 site, in, combination with the less hydrophobic/aromatic character of the B1, base-recognition site and a completely disrupted B2 base-recognition site, might account for this complete lack of activity.
About this Structure
1JY5 is a Single protein structure of sequence from Calystegia sepium. Full crystallographic information is available from OCA.
Reference
Structure of an RNase-related protein from Calystegia sepium., Rabijns A, Verboven C, Rouge P, Barre A, Van Damme EJ, Peumans WJ, De Ranter CJ, Acta Crystallogr D Biol Crystallogr. 2002 Apr;58(Pt 4):627-33. Epub 2002, Mar 22. PMID:11914487
Page seeded by OCA on Sun Nov 25 00:25:16 2007
