1k2j
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(New page: 200px<br /><applet load="1k2j" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k2j" /> '''NMR MINIMIZED AVERAGE STRUCTURE OF d(CGTACG)...)
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Revision as of 22:29, 24 November 2007
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NMR MINIMIZED AVERAGE STRUCTURE OF d(CGTACG)2
Overview
Solution structures and base pair stacking of a self- complementary DNA, hexamer d(CGTACG)(2) have been studied at 5, 10 and 15 degrees C, respectively. The stacking interactions among the center base pair steps, of the DNA duplex are found to improve when the terminal base pairs became, less stable due to end fraying. A new structural quantity, the stacking, sum (Sigma(s)), is introduced to indicate small changes in the stacking, overlaps between base pairs. The improvements in the stacking overlaps to, maintain the double helical conformation are probably the cause for the, observed temperature dependent structural changes in double helical DNA, molecule. A detailed analysis of the helical parameters, backbone torsion, angles, base orientations and sugar conformations of these structures has, been performed.
About this Structure
1K2J is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Low temperature solution structures and base pair stacking of double helical d(CGTACG)(2)., Lam SL, Ip LN, J Biomol Struct Dyn. 2002 Apr;19(5):907-17. PMID:11922844
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