1bwm
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(New page: 200px<br /><applet load="1bwm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bwm" /> '''A SINGLE-CHAIN T CELL RECEPTOR'''<br /> ==O...)
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Revision as of 22:35, 24 November 2007
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A SINGLE-CHAIN T CELL RECEPTOR
Overview
Using NMR spectroscopy, we determined the solution structure of a, single-chain T-cell receptor (scTCR) derived from the major, histocompatibility complex (MHC) class II-restricted D10 TCR. The, conformations of complementarity-determining regions (CDRs) 3beta and, 1alpha and surface properties of 2alpha are different from those of, related class I-restricted TCRs. We infer a conserved orientation for TCR, V(alpha) domains in complexes with both class I and II MHC-peptide, ligands, which implies that small structural variations in V(alpha) confer, MHC class preference. High mobility of CDR3 residues relative to other CDR, or framework residues (picosecond time scale) provides insight into immune, recognition and selection mechanisms.
About this Structure
1BWM is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor., Hare BJ, Wyss DF, Osburne MS, Kern PS, Reinherz EL, Wagner G, Nat Struct Biol. 1999 Jun;6(6):574-81. PMID:10360364
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