User:Lynmarie K Thompson/Sandbox 1

From Proteopedia

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Revision as of 18:23, 26 August 2009

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spinqualitylabelsall models 3fh6: maltose transporter resting state Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Let's compare the maltose transporter crystallized in the proposed resting state (left, 3fh6) and catalytic intermediate (right, 2r6g). Compare similar orientations of a single transporter, resting state , with inward-facing transmembrane domains (TMDs) and the nucleotide binding domains (NBDs) in an open state,

spinqualitylabelsall models 2r6g: maltose transporter intermediate state Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

and catalytic intermediate , with outward-facing transmembrane domains (TMDs) and the nucleotide binding domains (NBDs) in a closed state, plus bound ATP and MalE (the maltose binding protein).