User:Eric Martz/Sandbox 0
From Proteopedia
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<applet load='Insert PDB code or filename here' size='300' frame='true' align='right' caption='Insert caption here' /> | <applet load='Insert PDB code or filename here' size='300' frame='true' align='right' caption='Insert caption here' /> | ||
| - | A piece of string, or a protein chain, is deemed to contain a knot when pulling on the ends would leave a knot. When the ends of most folded protein chains are "pulled", they resolve to a straight chain between the pulled ends: no knot remains. Knots in protein chains are rare, and the mechanisms by which they form and their functions remain subjects of speculation<ref name="taylor2000">PMID: 10972297</ref>. A dramatic example, discovered in 2000<ref name="taylor2000" />, is illustrated here. | + | A piece of string, or a protein chain, is deemed to contain a knot when pulling on the ends would leave a knot. When the ends of most folded protein chains are "pulled", they resolve to a straight chain between the pulled ends: no knot remains. Knots in protein chains are rare, and the mechanisms by which they form and their functions remain subjects of speculation<ref name="taylor2000">PMID: 10972297</ref><ref name="taylor2007">PMID: 17500039</ref>. A dramatic example, discovered in 2000<ref name="taylor2000" />, is illustrated here. |
noncovalent pseudoknots <ref name="pseudoknots">PMID: 12798035</ref> | noncovalent pseudoknots <ref name="pseudoknots">PMID: 12798035</ref> | ||
Revision as of 00:16, 1 September 2009
Proposed Article Title: Knots in Proteins
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A piece of string, or a protein chain, is deemed to contain a knot when pulling on the ends would leave a knot. When the ends of most folded protein chains are "pulled", they resolve to a straight chain between the pulled ends: no knot remains. Knots in protein chains are rare, and the mechanisms by which they form and their functions remain subjects of speculation[1][2]. A dramatic example, discovered in 2000[1], is illustrated here.
noncovalent pseudoknots [3]
Notes & References
- ↑ 1.0 1.1 Taylor WR. A deeply knotted protein structure and how it might fold. Nature. 2000 Aug 24;406(6798):916-9. PMID:10972297 doi:10.1038/35022623
- ↑ Taylor WR. Protein knots and fold complexity: some new twists. Comput Biol Chem. 2007 Jun;31(3):151-62. Epub 2007 Mar 24. PMID:17500039 doi:10.1016/j.compbiolchem.2007.03.002
- ↑ Taylor WR, Xiao B, Gamblin SJ, Lin K. A knot or not a knot? SETting the record 'straight' on proteins. Comput Biol Chem. 2003 Feb;27(1):11-5. PMID:12798035
