User:Eric Martz/Sandbox 0
From Proteopedia
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A piece of string, or a protein chain, is deemed to contain a knot when pulling on the ends would leave a knot. When the ends of most folded protein chains are "pulled", they resolve to a straight chain between the pulled ends: no knot remains. Knots in protein chains are rare, and the mechanisms by which they form and their functions remain subjects of speculation<ref name="taylor2000">PMID: 10972297</ref><ref name="taylor2007">PMID: 17500039</ref>. A dramatic example, discovered in 2000<ref name="taylor2000" />, is illustrated here. | A piece of string, or a protein chain, is deemed to contain a knot when pulling on the ends would leave a knot. When the ends of most folded protein chains are "pulled", they resolve to a straight chain between the pulled ends: no knot remains. Knots in protein chains are rare, and the mechanisms by which they form and their functions remain subjects of speculation<ref name="taylor2000">PMID: 10972297</ref><ref name="taylor2007">PMID: 17500039</ref>. A dramatic example, discovered in 2000<ref name="taylor2000" />, is illustrated here. | ||
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| + | Because knotted proteins are so rare, efforts have been made to eliminate knotted models when attempting to predict a protein fold<ref>PMID: 19478000</ref>. | ||
noncovalent pseudoknots <ref name="pseudoknots">PMID: 12798035</ref> | noncovalent pseudoknots <ref name="pseudoknots">PMID: 12798035</ref> | ||
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| + | ??<ref>PMID: 19476499</ref> | ||
==Notes & References== | ==Notes & References== | ||
<references /> | <references /> | ||
Revision as of 00:22, 1 September 2009
Proposed Article Title: Knots in Proteins
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A piece of string, or a protein chain, is deemed to contain a knot when pulling on the ends would leave a knot. When the ends of most folded protein chains are "pulled", they resolve to a straight chain between the pulled ends: no knot remains. Knots in protein chains are rare, and the mechanisms by which they form and their functions remain subjects of speculation[1][2]. A dramatic example, discovered in 2000[1], is illustrated here.
Because knotted proteins are so rare, efforts have been made to eliminate knotted models when attempting to predict a protein fold[3].
noncovalent pseudoknots [4]
??[5]
Notes & References
- ↑ 1.0 1.1 Taylor WR. A deeply knotted protein structure and how it might fold. Nature. 2000 Aug 24;406(6798):916-9. PMID:10972297 doi:10.1038/35022623
- ↑ Taylor WR. Protein knots and fold complexity: some new twists. Comput Biol Chem. 2007 Jun;31(3):151-62. Epub 2007 Mar 24. PMID:17500039 doi:10.1016/j.compbiolchem.2007.03.002
- ↑ Khatib F, Rohl CA, Karplus K. Pokefind: a novel topological filter for use with protein structure prediction. Bioinformatics. 2009 Jun 15;25(12):i281-8. PMID:19478000 doi:10.1093/bioinformatics/btp198
- ↑ Taylor WR, Xiao B, Gamblin SJ, Lin K. A knot or not a knot? SETting the record 'straight' on proteins. Comput Biol Chem. 2003 Feb;27(1):11-5. PMID:12798035
- ↑ Andersson FI, Pina DG, Mallam AL, Blaser G, Jackson SE. Untangling the folding mechanism of the 5(2)-knotted protein UCH-L3. FEBS J. 2009 May;276(9):2625-35. Epub 2009 Mar 24. PMID:19476499 doi:10.1111/j.1742-4658.2009.06990.x
