1smz
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(New page: 200px<br /><applet load="1smz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1smz" /> '''Structure of Transportan in phospholipid bic...)
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Revision as of 22:40, 24 November 2007
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Structure of Transportan in phospholipid bicellar solution
Overview
Transportan is a chimeric cell-penetrating peptide constructed from the, peptides galanin and mastoparan, which has the ability to internalize, living cells carrying a hydrophilic load. In this study, we have, determined the NMR solution structure and investigated the position of, transportan in neutral bicelles. The structure revealed a well-defined, alpha-helix in the C-terminal mastoparan part of the peptide and a weaker, tendency to form an alpha-helix in the N-terminal domain. The position of, the peptide in relation to the membrane, as studied by adding paramagnetic, probes, shows that the peptide lies parallel to, and in the head-group, region of the membrane surface. This result is supported by amide proton, secondary chemical shifts.
About this Structure
1SMZ is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
NMR solution structure and position of transportan in neutral phospholipid bicelles., Barany-Wallje E, Andersson A, Graslund A, Maler L, FEBS Lett. 2004 Jun 4;567(2-3):265-9. PMID:15178334
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