1gwq

From Proteopedia

Revision as of 06:28, 30 October 2007

HUMAN OESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH RALOXIFENE CORE AND TIF2 NRBOX2 PEPTIDE

Overview

The activation function 2/ligand-dependent interaction between nuclear, receptors and their coregulators is mediated by a short consensus motif, the so-called nuclear receptor (NR) box. Nuclear receptors exhibit, distinct preferences for such motifs depending both on the bound ligand, and on the NR box sequence. To better understand the structural basis of, motif recognition, we characterized the interaction between estrogen, receptor alpha and the NR box regions of the p160 coactivator TIF2. We, have determined the crystal structures of complexes between the, ligand-binding domain of estrogen receptor alpha and 12-mer peptides from, the Box B2 and Box B3 regions of TIF2. Surprisingly, the Box B3 module, displays an unexpected binding mode that is distinct from the canonical, LXXLL ... [(full description)]

About this Structure

1GWQ is a [Protein complex] structure of sequences from [Homo sapiens] with ZTW as [ligand]. Structure known Active Site: ZWA. Full crystallographic information is available from [OCA].

Reference

Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor alpha., Warnmark A, Treuter E, Gustafsson JA, Hubbard RE, Brzozowski AM, Pike AC, J Biol Chem. 2002 Jun 14;277(24):21862-8. Epub 2002 Apr 5. PMID:11937504

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