1dyq
From Proteopedia
(New page: 200px<br /> <applet load="1dyq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dyq, resolution 1.50Å" /> '''STAPHYLOCOCCAL ENTE...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1DYQ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]] with ZN and SO4 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DYQ OCA]]. | + | 1DYQ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]] with ZN and SO4 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: ZN1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DYQ OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: vaccine]] | [[Category: vaccine]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:34:37 2007'' |
Revision as of 06:29, 30 October 2007
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STAPHYLOCOCCAL ENTEROTOXIN A MUTANT VACCINE
Overview
Staphylococcal enterotoxins (SEs) are superantigenic protein toxins, responsible for a number of life-threatening diseases. The X-ray structure, of a staphylococcal enterotoxin A (SEA) triple-mutant (L48R, D70R, and, Y92A) vaccine reveals a cascade of structural rearrangements located in, three loop regions essential for binding the alpha subunit of major, histocompatibility complex class II (MHC-II) molecules. A comparison of, hypothetical model complexes between SEA and the SEA triple mutant with, MHC-II HLA-DR1 clearly shows disruption of key ionic and hydrophobic, interactions necessary for forming the complex. Extensive dislocation of, the disulfide loop in particular interferes with MHC-IIalpha binding. The, triple-mutant structure provides new insights into the loss of, ... [(full description)]
About this Structure
1DYQ is a [Single protein] structure of sequence from [Staphylococcus aureus] with ZN and SO4 as [ligands]. Structure known Active Site: ZN1. Full crystallographic information is available from [OCA].
Reference
Structural basis for abrogated binding between staphylococcal enterotoxin A superantigen vaccine and MHC-IIalpha., Krupka HI, Segelke BW, Ulrich RG, Ringhofer S, Knapp M, Rupp B, Protein Sci. 2002 Mar;11(3):642-51. PMID:11847286
Page seeded by OCA on Tue Oct 30 08:34:37 2007
