3hki

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===Crystal structure of murine thrombin mutant W215A/E217A in complex with the extracellular fragment of human PAR1===
===Crystal structure of murine thrombin mutant W215A/E217A in complex with the extracellular fragment of human PAR1===
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{{ABSTRACT_PUBMED_19586901}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:19586901</ref><ref group="xtra">PMID:15252033</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 8 12:44:44 2009''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:25:32 2009''

Revision as of 05:25, 16 September 2009

Image:3hki.png

Template:STRUCTURE 3hki

Crystal structure of murine thrombin mutant W215A/E217A in complex with the extracellular fragment of human PAR1

Template:ABSTRACT PUBMED 19586901

About this Structure

3HKI is a 6 chains structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Gandhi PS, Page MJ, Chen Z, Bush-Pelc L, Di Cera E. Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A. J Biol Chem. 2009 Sep 4;284(36):24098-105. Epub 2009 Jul 8. PMID:19586901 doi:10.1074/jbc.M109.025403
  • Pineda AO, Chen ZW, Caccia S, Cantwell AM, Savvides SN, Waksman G, Mathews FS, Di Cera E. The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket. J Biol Chem. 2004 Sep 17;279(38):39824-8. Epub 2004 Jul 13. PMID:15252033 doi:http://dx.doi.org/10.1074/jbc.M407272200

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