3eig
From Proteopedia
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===Crystal structure of a methotrexate-resistant mutant of human dihydrofolate reductase=== | ===Crystal structure of a methotrexate-resistant mutant of human dihydrofolate reductase=== | ||
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==About this Structure== | ==About this Structure== | ||
3EIG is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIG OCA]. | 3EIG is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIG OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:19478082</ref><references group="xtra"/> | ||
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
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Revision as of 17:13, 21 September 2009
Crystal structure of a methotrexate-resistant mutant of human dihydrofolate reductase
Template:ABSTRACT PUBMED 19478082
About this Structure
3EIG is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Volpato JP, Yachnin BJ, Blanchet J, Guerrero V, Poulin L, Fossati E, Berghuis AM, Pelletier JN. Multiple conformers in active site of human dihydrofolate reductase F31R/Q35E double mutant suggest structural basis for methotrexate resistance. J Biol Chem. 2009 Jul 24;284(30):20079-89. Epub 2009 May 28. PMID:19478082 doi:10.1074/jbc.M109.018010
Page seeded by OCA on Mon Sep 21 20:13:36 2009
