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3f66

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==About this Structure==
==About this Structure==
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3F66 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F66 OCA].
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3F66 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F66 OCA].
==Reference==
==Reference==
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Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase., Porter J, Lumb S, Lecomte F, Reuberson J, Foley A, Calmiano M, le Riche K, Edwards H, Delgado J, Franklin RJ, Gascon-Simorte JM, Maloney A, Meier C, Batchelor M, Bioorg Med Chem Lett. 2008 Nov 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19059779 19059779]
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<ref group="xtra">PMID:19059779</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Single protein]]
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[[Category: Ceska, T.]]
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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[[Category: Meier, C.]]
[[Category: Alternative splicing]]
[[Category: Alternative splicing]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
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[[Category: Tyrosine-protein kinase.]]
[[Category: Tyrosine-protein kinase.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 7 20:11:06 2009''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 21 20:14:22 2009''

Revision as of 17:14, 21 September 2009

Template:STRUCTURE 3f66

Contents

Human c-Met Kinase in complex with quinoxaline inhibitor

Template:ABSTRACT PUBMED 19059779

Disease

Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[164860], Renal cell carcinoma, papillary, familial and sporadic OMIM:[164860], Autism, suseptibility to, 9 OMIM:[164860]

About this Structure

3F66 is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Porter J, Lumb S, Lecomte F, Reuberson J, Foley A, Calmiano M, le Riche K, Edwards H, Delgado J, Franklin RJ, Gascon-Simorte JM, Maloney A, Meier C, Batchelor M. Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase. Bioorg Med Chem Lett. 2009 Jan 15;19(2):397-400. Epub 2008 Nov 21. PMID:19059779 doi:10.1016/j.bmcl.2008.11.062

Page seeded by OCA on Mon Sep 21 20:14:22 2009

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