3hqy

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===Discovery of novel inhibitors of PDE10A===
===Discovery of novel inhibitors of PDE10A===
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{{ABSTRACT_PUBMED_19630403}}
==About this Structure==
==About this Structure==
3HQY is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HQY OCA].
3HQY is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HQY OCA].
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==Reference==
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<ref group="xtra">PMID:19630403</ref><references group="xtra"/>
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Marr, E S.]]
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[[Category: Zinc]]
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Revision as of 05:11, 23 September 2009

Image:3hqy.png

Template:STRUCTURE 3hqy

Discovery of novel inhibitors of PDE10A

Template:ABSTRACT PUBMED 19630403

About this Structure

3HQY is a 1 chain structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Verhoest PR, Chapin DS, Corman M, Fonseca K, Harms JF, Hou X, Marr ES, Menniti FS, Nelson F, O'Connor R, Pandit J, Proulx-Lafrance C, Schmidt AW, Schmidt CJ, Suiciak JA, Liras S. Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia (dagger) dagger Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1). J Med Chem. 2009 Jul 24. PMID:19630403 doi:10.1021/jm900521k

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