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3i5u

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Template:STRUCTURE 3i5u

Crystal structure of an O-methyltransferase (NcsB1) from neocarzinostatin biosynthesis in complex with S-adenosylmethionine (SAM) and 2-hydroxy-5-methyl naphthoic acid (MNA)

Template:ABSTRACT PUBMED 19702337

About this Structure

3i5u is a 2 chain structure with sequence from Streptomyces carzinostaticus subsp. neocarzinostaticus. Full crystallographic information is available from OCA.

Reference

  • Cooke HA, Guenther EL, Luo Y, Shen B, Bruner SD. Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. Biochemistry. 2009 Aug 25. PMID:19702337 doi:10.1021/bi901257q

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