3jq8

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Image:3jq8.png

Template:STRUCTURE 3jq8

Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6,7,7-trimethyl-7,8-dihydropteridine-2,4-diamine (DX3)

Template:ABSTRACT PUBMED 19916554

About this Structure

3JQ8 is a 4 chains structure with sequences from Trypanosoma brucei. This structure supersedes the now removed PDB entry 3bmf. Full crystallographic information is available from OCA.

Reference

  • Tulloch LB, Martini VP, Iulek J, Huggan JK, Lee JH, Gibson CL, Smith TK, Suckling CJ, Hunter WN. Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the Leishmaniases. J Med Chem. 2009 Nov 16. PMID:19916554 doi:10.1021/jm901059x

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