3kck

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Image:3kck.png

Template:STRUCTURE 3kck

Contents

A Novel Chemotype of Kinase Inhibitors

Template:ABSTRACT PUBMED 19945871

Disease

Known disease associated with this structure: Leukemia, acute myelogenous OMIM:[147796], Myelofibrosis, idiopathic OMIM:[147796], Myeloproliferative disorder with erythrocytosis OMIM:[147796], Polycythemia vera OMIM:[147796], Thrombocythemia, essential OMIM:[147796], Budd-Chiari syndrome OMIM:[147796]

About this Structure

3KCK is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Wang T, Ledeboer MW, Duffy JP, Salituro FG, Pierce AC, Zuccola HJ, Block E, Shlyakter D, Hogan JK, Bennani YL. A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors. Bioorg Med Chem Lett. 2010 Jan 1;20(1):153-6. Epub 2009 Nov 12. PMID:19945871 doi:10.1016/j.bmcl.2009.11.021

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