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3krr
From Proteopedia
Crystal Structure of JAK2 complexed with a potent quinoxaline ATP site inhibitor
Template:ABSTRACT PUBMED 20587663
About this Structure
3KRR is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Baffert F, Regnier CH, De Pover A, Pissot-Soldermann C, Tavares GA, Blasco F, Brueggen J, Chene P, Drueckes P, Erdmann D, Furet P, Gerspacher M, Lang M, Ledieu D, Nolan L, Ruetz S, Trappe J, Vangrevelinghe E, Wartmann M, Wyder L, Hofmann F, Radimerski T. Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Mol Cancer Ther. 2010 Jul;9(7):1945-55. Epub 2010 Jun 29. PMID:20587663 doi:10.1158/1535-7163.MCT-10-0053
Page seeded by OCA on Wed Jul 21 10:17:16 2010
Categories: Homo sapiens | Non-specific protein-tyrosine kinase | Gerspacher, M. | Kroemer, M. | Scheufler, C. | Tavares, G A. | Atp site kinase inhibitor | Atp-binding | Disease mutation | Kinase | Membrane | Nucleotide-binding | Phosphoprotein | Proto-oncogene | Sh2 domain | Small molecule inhibitor | Transferase | Tyrosine-protein kinase
