1z1y

From Proteopedia

Revision as of 14:11, 21 February 2008 by OCA (Talk | contribs)
Jump to: navigation, search
Image:1z1y.gif

1z1y, resolution 2.000Å

Drag the structure with the mouse to rotate

Crystal structure of Methylated Pvs25, an ookinete protein from Plasmodium vivax

Overview

P25 and P28 proteins are essential for Plasmodium parasites to infect mosquitoes and are leading candidates for a transmission-blocking malaria vaccine. The Plasmodium vivax P25 is a triangular prism that could tile the parasite surface. The residues forming the triangle are conserved in P25 and P28 from all Plasmodium species. A cocrystal structure shows that a transmission-blocking antibody uses only its heavy chain to bind Pvs25 at a vertex of the triangle.

About this Structure

1Z1Y is a Single protein structure of sequence from Plasmodium vivax with as ligand. Full crystallographic information is available from OCA.

Reference

The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms., Saxena AK, Singh K, Su HP, Klein MM, Stowers AW, Saul AJ, Long CA, Garboczi DN, Nat Struct Mol Biol. 2006 Jan;13(1):90-1. Epub 2005 Dec 4. PMID:16327807

Page seeded by OCA on Thu Feb 21 16:11:21 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1z1y"
Personal tools