3k5v

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Image:3k5v.png

Template:STRUCTURE 3k5v

Structure of Abl kinase in complex with imatinib and GNF-2

Template:ABSTRACT PUBMED 20072125

About this Structure

3K5V is a 2 chains structure with sequences from Abelson murine leukemia virus. Full crystallographic information is available from OCA.

Reference

  • Zhang J, Adrian FJ, Jahnke W, Cowan-Jacob SW, Li AG, Iacob RE, Sim T, Powers J, Dierks C, Sun F, Guo GR, Ding Q, Okram B, Choi Y, Wojciechowski A, Deng X, Liu G, Fendrich G, Strauss A, Vajpai N, Grzesiek S, Tuntland T, Liu Y, Bursulaya B, Azam M, Manley PW, Engen JR, Daley GQ, Warmuth M, Gray NS. Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature. 2010 Jan 28;463(7280):501-6. Epub 2010 Jan 13. PMID:20072125 doi:10.1038/nature08675

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