1hwg

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Image:1hwg.png

Template:STRUCTURE 1hwg

1:2 COMPLEX OF HUMAN GROWTH HORMONE WITH ITS SOLUBLE BINDING PROTEIN

Template:ABSTRACT PUBMED 8943276

About this Structure

1hwg is a 3 chain structure with sequence from Homo sapiens. The April 2004 RCSB PDB Molecule of the Month feature on Growth Hormone by Shuchismita Dutta and David S. Goodsell is 10.2210/rcsb_pdb/mom_2004_4. Full crystallographic information is available from OCA.

Reference

  • Sundstrom M, Lundqvist T, Rodin J, Giebel LB, Milligan D, Norstedt G. Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution. J Biol Chem. 1996 Dec 13;271(50):32197-203. PMID:8943276
  • Duda KM, Brooks CL. Identification of residues outside the two binding sites that are critical for activation of the lactogenic activity of human growth hormone. J Biol Chem. 2003 Jun 20;278(25):22734-9. Epub 2003 Apr 7. PMID:12682073 doi:10.1074/jbc.M212550200

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