3lc5

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Image:3lc5.jpg

Template:STRUCTURE 3lc5

Contents

Selective Benzothiophine Inhibitors of Factor IXa

Template:ABSTRACT PUBMED 20121197

Disease

Known disease associated with this structure: Hemophilia B OMIM:[300746]

About this Structure

3LC5 is a 2 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Wang S, Beck R, Burd A, Blench T, Marlin F, Ayele T, Buxton S, Dagostin C, Malic M, Joshi R, Barry J, Sajad M, Cheung C, Shaikh S, Chahwala S, Chander C, Baumgartner C, Holthoff HP, Murray E, Blackney M, Giddings A. Structure Based Drug Design: Development of Potent and Selective Factor IXa (FIXa) Inhibitors. J Med Chem. 2010 Feb 25;53(4):1473-82. PMID:20121197 doi:10.1021/jm901476x

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