3lok

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Image:3lok.jpg

Template:STRUCTURE 3lok

Drug resistant cSrc kinase domain in complex with covalent inhibitor PD168393

Template:ABSTRACT PUBMED 21080395

About this Structure

3LOK is a 2 chains structure with sequences from Gallus gallus. Full crystallographic information is available from OCA.

Reference

  • Kluter S, Simard JR, Rode HB, Grutter C, Pawar V, Raaijmakers HC, Barf TA, Rabiller M, van Otterlo WA, Rauh D. Characterization of irreversible kinase inhibitors by directly detecting covalent bond formation: a tool for dissecting kinase drug resistance. Chembiochem. 2010 Dec 10;11(18):2557-66. PMID:21080395 doi:10.1002/cbic.201000352

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