Molecular playground/beta 2 microglobulin
From Proteopedia
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is a 12kd protein that self-assembles into amyloid fibrils in the presence of copper. This reaction is considered a likely cause for dialysis related amyloidosis; a disease where these fibrils build up in joints causing pain and eventually necessitating joint replacement.
The proposed mechanism for
formation is that the copper binds near the N-terminal of the protein, this binding causes structural shifts throughout the protein creating two new planes that interact favorably.
