This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Severin

From Proteopedia

Jump to: navigation, search
Image:3fg6.png

Template:STRUCTURE 3fg6

3D Structure of Severin


Actin Binding Protein

Severin is a calcium-activated protein which binds actin. It nucleates actin assembly, severes F-actin and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins. Severin comprises 6 homologous domains (A1-A6), which share 60% identity with the 6 domains from Gelsolin (G1-G6). It is named Adseverin and Scinderin as well. The image at the right is a (each monomer is colored in different colors) of the Severin with (colored lime).

3D Structures of Severin

3fg6 – Adseverin C-terminal – human
1svy – Severin domain 2 – Dictyostelium discoideum
1svq - Severin domain 2 - Dictyostelium discoideum, NMR

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/Severin"
Personal tools