3nbp

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Image:3nbp.jpg

Template:STRUCTURE 3nbp

HIV-1 reverse transcriptase with aminopyrimidine inhibitor 2

Template:ABSTRACT PUBMED 20538456

About this Structure

3NBP is a 2 chains structure with sequences from Human immunodeficiency virus type 1 group m subtype b. Full crystallographic information is available from OCA.

Reference

  • Kertesz DJ, Brotherton-Pleiss C, Yang M, Wang Z, Lin X, Qiu Z, Hirschfeld DR, Gleason S, Mirzadegan T, Dunten PW, Harris SF, Villasenor AG, Hang JQ, Heilek GM, Klumpp K. Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4215-8. Epub 2010 May 16. PMID:20538456 doi:10.1016/j.bmcl.2010.05.040

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