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3o46

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Template:STRUCTURE 3o46

Contents

Crystal structure of the PDZ domain of MPP7

Function

[MPP7_HUMAN] Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact.[1]

About this Structure

3o46 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Stucke VM, Timmerman E, Vandekerckhove J, Gevaert K, Hall A. The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation. Mol Biol Cell. 2007 May;18(5):1744-55. Epub 2007 Mar 1. PMID:17332497 doi:10.1091/mbc.E06-11-0980

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