3kho

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Template:STRUCTURE 3kho

Contents

Crystal structure of murine Ig-beta (CD79b) homodimer

Template:ABSTRACT PUBMED 20696394

Function

[CD79B_MOUSE] Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.[1] [2] [3] [4]

About this Structure

3kho is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Radaev S, Zou Z, Tolar P, Nguyen K, Nguyen A, Krueger PD, Stutzman N, Pierce S, Sun PD. Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor. Structure. 2010 Aug 11;18(8):934-43. PMID:20696394 doi:10.1016/j.str.2010.04.019
  1. ↑ Taddie JA, Hurley TR, Hardwick BS, Sefton BM. Activation of B- and T-cells by the cytoplasmic domains of the B-cell antigen receptor proteins Ig-alpha and Ig-beta. J Biol Chem. 1994 May 6;269(18):13529-35. PMID:8175787
  2. ↑ Siemasko K, Eisfelder BJ, Stebbins C, Kabak S, Sant AJ, Song W, Clark MR. Ig alpha and Ig beta are required for efficient trafficking to late endosomes and to enhance antigen presentation. J Immunol. 1999 Jun 1;162(11):6518-25. PMID:10352267
  3. ↑ Li C, Siemasko K, Clark MR, Song W. Cooperative interaction of Ig(alpha) and Ig(beta) of the BCR regulates the kinetics and specificity of antigen targeting. Int Immunol. 2002 Oct;14(10):1179-91. PMID:12356683
  4. ↑ Fuentes-Panana EM, Bannish G, van der Voort D, King LB, Monroe JG. Ig alpha/Ig beta complexes generate signals for B cell development independent of selective plasma membrane compartmentalization. J Immunol. 2005 Feb 1;174(3):1245-52. PMID:15661879

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