3m1c

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Template:STRUCTURE 3m1c

Contents 1 Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL 2 Function 3 About this Structure 4 Reference

Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL

Template:ABSTRACT PUBMED 20601960

Function

[GH_HHV2H] The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis (By similarity). [GL_HHV2H] The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL (By similarity).

About this Structure

3m1c is a 2 chain structure with sequence from Human herpesvirus 2. Full crystallographic information is available from OCA.

Reference

• Chowdary TK, Cairns TM, Atanasiu D, Cohen GH, Eisenberg RJ, Heldwein EE. Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL. Nat Struct Mol Biol. 2010 Jul;17(7):882-8. Epub 2010 Jul 4. PMID:20601960 doi:10.1038/nsmb.1837