This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1a1r
From Proteopedia
|
HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX
Overview
An estimated 1% of the global human population is infected by hepatitis C, viruses (HCVs), and there are no broadly effective treatments for the, debilitating progression of chronic hepatitis C. A serine protease located, within the HCV NS3 protein processes the viral polyprotein at four, specific sites and is considered essential for replication. Thus, it, emerges as an attractive target for drug design. We report here the 2.5, angstrom resolution X-ray crystal structure of the NS3 protease domain, complexed with a synthetic NS4A activator peptide. The protease has a, chymotrypsin-like fold and features a tetrahedrally coordinated metal ion, distal to the active site. The NS4A peptide intercalates within a beta, sheet of the enzyme core.
About this Structure
1A1R is a Protein complex structure of sequences from Gb virus c with as ligand. Known structural/functional Sites: , , and . Full crystallographic information is available from OCA.
Reference
Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide., Kim JL, Morgenstern KA, Lin C, Fox T, Dwyer MD, Landro JA, Chambers SP, Markland W, Lepre CA, O'Malley ET, Harbeson SL, Rice CM, Murcko MA, Caron PR, Thomson JA, Cell. 1996 Oct 18;87(2):343-55. PMID:8861917
Page seeded by OCA on Wed Dec 19 11:13:18 2007
Categories: Gb virus c | Protein complex | Caron, P.R. | Chambers, S.P. | Dwyer, M.D. | Fox, T. | Harbeson, S.L. | Kim, J.L. | Landro, J.A. | Lepre, C.A. | Lin, C. | Malley, E.T.O. | Markland, W. | Morgenstern, K.A. | Murcko, M.A. | Rice, C.M. | Thomson, J.A. | ZN | Cofactor peptide | Helicase | Nonstructural proteins | Serine protease | Viral protein
