3jsk
From Proteopedia
Contents |
Thiazole synthase from Neurospora crassa
Function
[Q9HGR2_NEUCR] Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance (By similarity).[1]
About this Structure
3jsk is a 16 chain structure with sequence from Neurospora crassa. Full crystallographic information is available from OCA.
Reference
- ↑ Faou P, Tropschug M. Neurospora crassa CyPBP37: a cytosolic stress protein that is able to replace yeast Thi4p function in the synthesis of vitamin B1. J Mol Biol. 2004 Dec 3;344(4):1147-57. PMID:15544818 doi:10.1016/j.jmb.2004.09.097
