This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2zaz

From Proteopedia

Revision as of 17:01, 21 February 2008 by OCA (Talk | contribs)
Jump to: navigation, search
Image:2zaz.jpg

2zaz, resolution 1.800Å

Drag the structure with the mouse to rotate

Crystal structure of P38 in complex with 4-anilino quinoline inhibitor

Overview

The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.

About this Structure

2ZAZ is a Single protein structure of sequence from Homo sapiens with , and as ligands. Active as Mitogen-activated protein kinase, with EC number 2.7.11.24 Full crystallographic information is available from OCA.

Reference

Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode., Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL, Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19. PMID:18006306

Page seeded by OCA on Thu Feb 21 19:01:10 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2zaz"
Personal tools